The treatment of the secondary abc is based on the appropriate treatment for the underlying tumor. Phosphaturic mesenchymal tumor with chondromyxoid fibroma like feature. Chondromyxoid fibroma is a type of cartilaginous tumor. Chondromyxoid fibroma is a rare benign bone tumor accounting for approximately 1% of all benign bone tumors. Chondromyxoid fibroma of the sacrum and left iliac bone md.
A chondromyxoid fibroma appears in imaging as a lesion with a border that resembles soap bubbles. Chondromyxoid fibroma cmf is a benign tumor characterized by lobules of spindle shaped or stellate cells in an abondant myxoid to chondroid stroma. Murata h, horie n, matsui t, akai t, ueda h, oshima y, konishi e, kubo t. Representative radiologic images of pelvic chondromyxoid fibroma. We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate.
Chondromyxoid fibroma cmf is a rare, benign bone tumour. An uncommon benign cartilaginous neoplasm arising from the bone. Backgroundchondromyxoid fibroma is a rare benign primary bone tumor of cartilage. Cmf is most often found in the long tubular bones, especially the tibia. In fact, the literature describes 18 cases of this form of neoplasia arising in the skull, only 4 of these having originated in the temporal bone. Chondromyxoid fibroma definition of chondromyxoid fibroma. July 27, 2017 056 the tumor may be discovered incidentally during radiography 1. If you have symptoms of cmf, your doctors will use imaging scans such as xrays, ct, and. Most cases are characterised by grm1 gene fusion or promoter swapping. Since this is the least common bone tumor of cartilaginous origin, it is highly unusual to find this tumor in the skull.
A primary chondromyxoid fibroma cmf arising from sternum is quite uncommon tumor in thoracic surgery. A chondromyxoid fibroma cmf is an extremely rare benign cartilaginous neoplasm which accounts for sep 24, 2018 cappelle s, pans s, sciot r. Citations may include links to fulltext content from pubmed central and publisher web sites. In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues.
The imaging and tissue tests help your doctor differentiate. To evaluate the frequency of radiologic and histologic manifestations of matrix calcification in chondromyxoid fibromas. The radiological features demonstrated by xray and magnetic resonance imaging mri are discussed. It was dense on plain ct scan and showed no convincing contrast enhancement. Jan 02, 2017 on mri, chondromyxoid fibroma shows a multilobulated pattern, with low signal intensity on t1weighted images and high signal intensity on t2weighted images. It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. Jan 08, 2015 chondromyxoid fibroma cmf is a rare, benign tumor of the bone that was described by jaffe and lichenstein in 1948. Enneking msts staging system the enneking surgical staging system also known as the msts system for benign musculoskeletal tumors is based on radiographic characteristics of the tumor host margin. Chondromyxoid fibroma may occur anywhere in the skeleton, but almost half of the cases occur around the knee. Chondromyxoid fibroma cmf is a relatively uncommon benign bone. Details of the image chondromyxoid fibroma modality. Chondromyxoid fibroma with secondary aneurysmal bone cyst in.
A case of chondromyxoid fibroma cmf involving the zygoma is presented. Chondromyxoid fibroma, pediatric orthopaedic society of north america posna 1 tower ln, suite 2410 oakbrook terrace, il 60181 p. We present the case of a 44yearold woman with chondromyxoid fibroma of temporal bone origin. Anderson cancer center chondromyxoid fibroma of the sacrum and left iliac bone sumit mehta1 janio szklaruk silvana c. Surgical management of a giant sternal chondromyxoid. Chondromyxoid fibroma is a very rare benign cartilaginous tumor representing less than 0. Murata h, horie n, matsui t, akai t, ueda h, oshima y, et al. Chondromyxoid fibroma typically occurs in children and young adults between the ages of 10 and 30, and accounts for less than 1 percent of all bone tumors. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for imaging differential diagnosis. Radiological evaluation of a chondromyxoid fibroma heighpubs. Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping.
Preferred sites proximal tibia 30 % of cases, small bones of the foot, and pelvis. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone. The possibility of chondromyxoid fibroma should always be considered when a focal bone lesion is evaluated that has geographic bone destruction, a sclerotic rim, lobulated margins, and septation. Plain skull films showed a round radiolucent mass with a sclerotic margin. Chondromyxoid fibroma cmf is a rare, benign bone tumor found most often in the bones of the legs, arms, feet, hands, fingers and toes. The preoperative diagnosis of chondromyxoid fibroma at an unusual location, as in this case, is difficult from the imaging examinations, or sometimes even from the histological examination of. The most commonly affected area is the metaphysial region of the proximal tibia and the distal femur 2. Cartilage is a rubberlike tissue that cushions and protects the ends of your bones, sits in between the disks in your spine, and makes up the ear and nose. Chondromyxoid fibroma of frontal bone is a rare lesion.
Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Tumors located in the distal extremities such as the hands or feet may only present clinically with signs of painless swelling 5. The possibility of chondromyxoid fibroma should always be considered when a focal bone. The purpose of our study was to describe the mr imaging characteristics of fibroma of the tendon sheath.
Chondromyxoid fibroma, or cmf, is a tumor of the cartilage found between your bones. Chondromyxoid fibroma, curettage, cementation, functional outcome, case series, management, protocol background chondromyxoid fibroma cmf is a rare, benign bone tumour. Chondromyxoid fibroma cmf is a rare, benign tumor of the bone that was described by jaffe and lichenstein in 1948. A rare case of epiphyseal chondromyxoid fibroma of the. B, microscopic image of chondromyxoid fibroma showing a. Chondromyxoid fibroma cmf is a rare benign bony tumour. Chondromyxoid fibromas demonstrate enhancement on postcontrast ct views. The imaging and tissue tests help your doctor differentiate cmf from other tumors that have a similar appearance, such as giant cell tumor, enchondroma, chondroma, nonossifying fibroma, aneurysmal bone cyst, or infection of the bone osteomyelitis. Complete local excision with tumorfree margins avoids the recurrence of cmf, the underlying tumor in this case report. Removal of giant sternal tumors requires extensive resection of the anterior chest.
This is an advanced case of a benign chondromyxoid fibroma. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture. Chondromyxoid fibroma of the sacrum and left iliac bone. To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton exclusive of the cranium. Baker ac, rezeanu l, o laughlin s, unni k, klein mj, et al. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture, diaphyseal location. Radiological evaluation of a chondromyxoid fibroma published. Chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation.
Chondromyxoid fibroma of the frontal bone tatsuo morimura, 12 atsuhisa nakano, 1 tsuyoshi matsumoto, 1 and eiichi tani1 summary. Under a microscope, chondromyxoid fibromas have elements of benign cartilage chondroid, myxoid, and fibrous tissue. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or. The age range of the patients was 370 years average 29 years. Chondromyxoid fibroma cmf is a relatively uncommon benign bone tumor of cartilaginous differentiation. The decisive role played by the radiologist in identifying the benign nature of the lesion is emphasized. Introduction chondromyxoid fibromas are rare, benign tumours that consist of immature myxoid mesenchymal tissue with features of primitive cartilaginous differentiation. We report on a case of chondromyxoid fibroma involving two adjacent thoracic vertebrae with features of aggressive behaviour on radiographs, ct and mri. Clinical usefulness of thallium201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Sep 12, 2014 chondromyxoid fibroma cmf is a rare, benign bone tumour. Pubmed comprises more than 26 million citations for biomedical literature from medline, life science journals, and online books. Sep 23, 2016 chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. With contrast injection, the central portion of the lesion may show no enhancement due to the myxoid component. Citations may include links to fulltext content from pubmed central and.
It is associated with high local recurrence rates with a small risk imaging. Mehta s, szklaruk j, faria sc, raymond ak, whitman gj. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mim. Chondromyxoid fibroma of two thoracic vertebrae, skeletal. Chondromyxoid fibroma cmf is a very rare, benign noncancerous tumor that most often develops in older children and young adults. To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton. Radiographic and histologic patterns of calcification in. The classic site of involvement is the metaphyseal region of long tubular bones, usually presenting in the second to third decades of life with nonspecific pain and swelling of the affected part. It is associated with high local recurrence rates with a small risk aug 07, 2016 chondromyxoid fibroma location. The lesion is never purely epiphyseal, but may extend into the subchondral b. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor accounting for less than 1% of all bone tumors.
It is characterized by the presence of spindleshaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and. Chondromyxoid fibroma childrens hospital of philadelphia. Calcification was found microscopically in 15 cases 34. Ct also readily depicts the cortical integrity of the lesion. Differential diagnosis of cartilaginous lesions of bone archives of. The primary pitfall in the histopathologic diagnosis of cmf is confusion. Males have a higher incidence, with no other demographic bias 3. The primary pitfall in the histopathologic diagnosis of cmf is confusion with a highgrade chondrosarcoma, owing to the atypical stellate and spindled cells set within a chondromyxoid background. Chondromyxoid fibroma can be classified based on imaging findings. Cmf is most often found in the long tubular bones, especially the tibia and femur near the knee joint. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. Department of oral pathology, emory university a case of chondromyxoid fibroma in the mandible of a 12yearold boy is reported.
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